abstract：Purpose:To investigate the potential of statistical and machine learning approaches to determine the diabetic status of patients from optical coherence tomography angiography (OCT-A) images. Methods:This was a retrospective cross-sectional observational study based at Manchester Royal Eye Hospital, United Kingdom. OCT...

journal_title：Translational vision science & technology

authors： Aslam TM,Hoyle DC,Puri V,Bento G

更新日期：2020-03-09 00:00:00

abstract：Purpose:To evaluate the safety and tolerability of a microsphere thermo-responsive hydrogel drug delivery system (DDS) loaded with aflibercept in a nonhuman primate model. Methods:A sterile 50 µL of aflibercept-loaded microsphere thermo-responsive hydrogel-DDS (aflibercept-DDS) was injected intravitreally into the rig...

journal_title：Translational vision science & technology

authors： Kim S,Kang-Mieler JJ,Liu W,Wang Z,Yiu G,Teixeira LBC,Mieler WF,Thomasy SM

更新日期：2020-02-27 00:00:00

abstract：Purpose:To present an overview of current machine learning methods and their use in medical research, focusing on select machine learning techniques, best practices, and deep learning. Methods:A systematic literature search in PubMed was performed for articles pertinent to the topic of artificial intelligence methods ...

journal_title：Translational vision science & technology

authors： Choi RY,Coyner AS,Kalpathy-Cramer J,Chiang MF,Campbell JP

更新日期：2020-02-27 00:00:00

abstract：Purpose:In vivo evaluation of corneal biomechanics holds the potential for improving diagnosis and management of ocular diseases. We aimed to develop an ocular pulse elastography (OPE) technique to quantify corneal strains generated by naturally occurring pulsations of the intraocular pressure (IOP) using high-frequenc...

journal_title：Translational vision science & technology

authors： Clayson K,Pavlatos E,Pan X,Sandwisch T,Ma Y,Liu J

更新日期：2020-01-30 00:00:00

abstract：Purpose:To evaluate the in vivo biocompatibility of photopolymerized poly(ethylene glycol) diacrylate (PEGDA) intrastromal inlays in rabbit corneas. Methods:Sixty-three eyes of 42 New Zealand rabbits were included. Manual intrastromal pockets were dissected in 42 eyes. PEGDA inlays were obtained using a specifically d...

journal_title：Translational vision science & technology

authors： Bidaguren A,Mendicute J,Madarieta I,Garagorri N

更新日期：2019-12-18 00:00:00

abstract：Purpose:The aim of the present study was to analyze quantitative optical coherence tomography (OCT) and OCT angiography (OCTA) parameters to identify clinically relevant cutoff values able to detect clinically different Stargardt's disease (STGD) subgroups. Methods:Consecutive STGD patients were recruited and underwen...

journal_title：Translational vision science & technology

authors： Arrigo A,Romano F,Aragona E,di Nunzio C,Sperti A,Bandello F,Battaglia Parodi M

更新日期：2019-12-05 00:00:00

abstract：Purpose:Detection of the huge amount of data generated in real-time visual evoked potential (VEP) requires labor-intensive work and experienced electrophysiologists. This study aims to build an automatic VEP classification system by using a deep learning algorithm. Methods:Patients with sellar region tumor and optic c...

journal_title：Translational vision science & technology

authors： Qiao N,Song M,Ye Z,He W,Ma Z,Wang Y,Zhang Y,Shou X

更新日期：2019-11-20 00:00:00

abstract：Purpose:To evaluate dysfunction in various ocular surface diseases (OSDs) including primary meibomian gland disease (MGD), perennial allergic conjunctivitis, and primary and secondary Sjögren syndromes. Methods:A retrospective analysis of 146 patients (111 women and 35 men) with symptomatic OSDs was performed. Patient...

journal_title：Translational vision science & technology

authors： Robin M,Liang H,Rabut G,Augstburger E,Baudouin C,Labbé A

更新日期：2019-11-12 00:00:00

abstract：Purpose:To create hybrid three-dimensional (3D) models of the choroidal vasculature from swept-source optical coherence tomography (SS-OCT) angiography images and to evaluate the model's characteristics. Methods:This study used prospective, noncomparative case series, including 21 eyes of 21 healthy individuals. The 6...

journal_title：Translational vision science & technology

authors： Sekiryu T,Sugano Y,Ojima A,Mori T,Furuta M,Okamoto M,Eifuku S

更新日期：2019-10-22 00:00:00

abstract：Purpose:Noninvasive keratograph break up times (NIKBUTs) are preferred to dye-based methods to evaluate tear stability in translational medicine. We analyzed the NIKBUTs in different regions of the precorneal tear by using a common imaging technology and explored potential correlations with clinical parameters. Method...

journal_title：Translational vision science & technology

authors： Tong L,Teo CHY,Lee RKJ

更新日期：2019-10-17 00:00:00

abstract：Purpose:To compare the antimicrobial effect of topical anesthetics, antivirals, antibiotics, and biocides on the viability of Acanthamoeba cysts and trophozoites in vitro. Methods:Amoebicidal and cysticidal assays were performed against both trophozoites and cysts of Acanthamoeba castellanii (ATCC 50370) and Acanthamo...

journal_title：Translational vision science & technology

authors： Heaselgrave W,Hamad A,Coles S,Hau S

更新日期：2019-09-25 00:00:00

abstract：Purpose:To image the human trabecular meshwork (TM) in vivo using adaptive optics gonioscopy (AOG) with approximately 2-μm lateral resolution. Methods:An existing Indiana University adaptive optics scanning laser ophthalmoscope was altered by adding a 12-mm button lens to a clinical gonioscopic lens allowing high-reso...

journal_title：Translational vision science & technology

authors： King BJ,Burns SA,Sapoznik KA,Luo T,Gast TJ

更新日期：2019-09-11 00:00:00

abstract：Purpose:To develop an eye model with a physiological blink mechanism. Methods:All parts of the eye model were designed using computer-aided design software. The eyelid consisted of a unique 3D printed structure containing teeth to physically secure a flexible membrane. Both the eyeball and eyelid membrane were synthes...

journal_title：Translational vision science & technology

authors： Phan CM,Walther H,Qiao H,Shinde R,Jones L

更新日期：2019-09-03 00:00:00

abstract：Purpose:To evaluate the relationships between refractive error, axial length (AL), and retinal vascular oxygen saturation in an adult population. Methods:This was a hospital-based, prospective observational study. The left eyes of phakic adult subjects without media opacity were analyzed. Subjective undilated manifest...

journal_title：Translational vision science & technology

authors： Lim LS,Lim XH,Tan L

更新日期：2019-08-07 00:00:00

abstract：Purpose:The posthatching chicken is a valuable animal model for research, but molecular tools needed for altering its gene expression are not yet available. Our purpose here was to adapt the adeno-associated viral (AAV) vector method, used widely in mammalian studies, for use in investigations of the chicken retina. We...

journal_title：Translational vision science & technology

authors： Waldner DM,Visser F,Fischer AJ,Bech-Hansen NT,Stell WK

更新日期：2019-07-01 00:00:00

abstract：Purpose:We developed and evaluated an eye dropper bottle sensor system comprising motion sensor with automatic motion waveform analysis using deep learning (DL) to accurately measure adherence of patients with antiglaucoma ophthalmic solution therapy. Methods:We enrolled 20 patients with open-angle glaucoma who were t...

journal_title：Translational vision science & technology

authors： Nishimura K,Tabuchi H,Nakakura S,Nakatani Y,Yorihiro A,Hasegawa S,Tanabe H,Noguchi A,Aoki R,Kiuchi Y

更新日期：2019-06-27 00:00:00

abstract：Purpose:We evaluate the antimicrobial effect of toluidine blue O (TBO)-mediated photodynamic antimicrobial chemotherapy (PACT) on Staphylococcus epidermidis and Staphylococcus aureus isolated from ocular surface infection. Methods:We selected 24 strains of bacteria for this study. The antimicrobial effect of different...

journal_title：Translational vision science & technology

authors： Shen J,Liang Q,Su G,Zhang Y,Wang Z,Baudouin C,Labbé A

更新日期：2019-06-21 00:00:00

abstract：Purpose:To investigate variation and determinants of macular layers, peripapillary retinal nerve fiber layer (pRNFL) and Bruch's membrane opening-minimum rim width (BMO-MRW) in the general population. Methods:In 1306 participants, we performed spectral domain optical coherence tomography (SD-OCT) scans of the macula, ...

journal_title：Translational vision science & technology

authors： Mauschitz MM,Holz FG,Finger RP,Breteler MMB

更新日期：2019-06-04 00:00:00

abstract：Purpose:The purpose of this study is to evaluate whether a single best image can represent central endothelial cell density (ECD) in corneas of differing cell size coefficient of variance (CV). Methods:Four hundred one healthy eyes but with variant CV values were enrolled. For each eye, three nonoverlapping central co...

journal_title：Translational vision science & technology

authors： Shi Y,Huang J,Baghdasaryan E,Huang P,Huang X,Sadda SR,Lee OL

更新日期：2019-05-29 00:00:00

abstract：Purpose:To assess the influence of an outdoor program on myopia progression in school children. Methods:The prospective interventional school-based study included 373 students aged 6 to 7 years (grade 1 or 2) who were examined annually between 2012 and 2016. Between 2012 and 2013, the children in the study group (n = ...

journal_title：Translational vision science & technology

authors： Guo Y,Liu L,Lv Y,Tang P,Feng Y,Wu M,Xu L,Jonas JB

更新日期：2019-05-02 00:00:00

abstract：:[This corrects the article DOI: 10.1167/tvst.8.2.3.]. ...

journal_title：Translational vision science & technology

authors：

更新日期：2019-05-02 00:00:00

abstract：Purpose:To determine the relationship between the progression of geographic atrophy (GA) and its baseline area (BA) using the square root transformation (sqrt) for different atrophy sizes. Methods:Single eyes of patients with GA visiting the Institut de la Màcula (Barcelona, Spain) between December 2009 and January 20...

journal_title：Translational vision science & technology

authors： Monés J,Biarnés M

更新日期：2018-12-28 00:00:00

abstract：Purpose:Gelatinous drop-like corneal dystrophy (GDLD) is a rare autosomal recessive corneal dystrophy that causes severe vision loss. Because of its poor prognosis, there is a demand for novel treatments for GDLD. Here, we establish a new in vitro disease model of GDLD based on immortalized human corneal epithelial (HC...

journal_title：Translational vision science & technology

authors： Xu P,Kai C,Kawasaki S,Kobayashi Y,Yamamoto K,Tsujikawa M,Hayashi R,Nishida K

更新日期：2018-12-21 00:00:00

abstract：Purpose:The activation of microglia, the primary innate immune cell resident in the retina, produces inflammatory mediators, which underlie changes in diabetic retinopathy including increased vascular permeability. This study evaluates the safety and efficacy of dextromethorphan, a drug capable of inhibiting microglial...

journal_title：Translational vision science & technology

authors： Valent DJ,Wong WT,Chew EY,Cukras CA

更新日期：2018-12-17 00:00:00

abstract：Purpose:To compare the diagnostic ability of the vessel parameters in macular and peripapillary regions measured using spectral-domain optical coherence tomography angiography (SD-OCTA) in differentiating primary open-angle glaucoma (POAG) from healthy eyes. Methods:POAG patients and healthy subjects underwent 6 × 6-m...

journal_title：Translational vision science & technology

authors： Richter GM,Chang R,Situ B,Chu Z,Burkemper B,Reznik A,Bedrood S,Kashani AH,Varma R,Wang RK

更新日期：2018-12-06 00:00:00

abstract：Purpose:We present a new method for analyzing relative corneal refractive power (RCRP) in children undergoing orthokeratology and explore its potential association to effective myopic control. Methods:A total of 55 children aged 8 to 12 years participated in the study. Axial growth was calculated as the difference in ...

journal_title：Translational vision science & technology

authors： Wang J,Yang D,Bi H,Du B,Lin W,Gu T,Zhang B,Wei R

更新日期：2018-11-30 00:00:00

abstract：Purpose:To explore the difference of the default mode network (DMN) in patients with retinal detachment (RD) by the study of the resting state functional connectivity (rs-FC). Methods:A total of 30 patients with RD (16 men, 14 women) and 30 similarly matched normal controls (NCs) were examined and recorded with rs-fMR...

journal_title：Translational vision science & technology

authors： Su T,Shu YQ,Liu KC,Ye L,Chen LL,Shi WQ,Min YL,Xu XW,Yuan Q,Zhu PW,Shao Y

更新日期：2018-11-30 00:00:00

abstract：Purpose:The Bayesian adaptive quick contrast sensitivity function (qCSF) method with a 10-letter identification task provides an efficient CSF assessment. However, large populations are unfamiliar with letters and cannot benefit from this test. To overcome the barrier, we conducted this study. Method:A new font for di...

journal_title：Translational vision science & technology

authors： Zheng H,Wang C,Cui R,He X,Shen M,Lesmes LA,Lu ZL,Qu J,Hou F

更新日期：2018-11-14 00:00:00

abstract：Purpose:Electronic retinal prostheses restore vision in people with outer retinal degeneration by electrically stimulating the inner retina. We characterized visual cortex electrophysiologic response elicited by electrical stimulation of retina in normally sighted and retinal degenerate rats. Methods:Nine normally sig...

journal_title：Translational vision science & technology

authors： Nimmagadda K,Weiland JD

更新日期：2018-10-31 00:00:00

abstract：Purpose:Accommodating intraocular lenses (A-IOLs) require capturing the ciliary muscle forces. Prior work demonstrated strong photo-initiated bonding between strips of capsular bag and poly(2-hydroxyethyl methacrylate); (pHEMA) polymer in an extraocular setting. We demonstrate that photobonding can be achieved intraocu...

journal_title：Translational vision science & technology

authors： Alejandre-Alba N,Gutierrez-Contreras R,Dorronsoro C,Marcos S

更新日期：2018-10-11 00:00:00

abstract：Purpose:Corneal neovascularization (CoNV) is a major risk factor for corneal graft rejection and other corneal conditions. The maturity of CoNV is important to guide treatment. This study investigated associations between clinical and angiographic characteristics of CoNV. Methods:In a prospective cross-sectional study...

journal_title：Translational vision science & technology

authors： Palme C,Romano V,Brunner M,Vinciguerra R,Kaye SB,Steger B

更新日期：2018-10-01 00:00:00

abstract：Purpose:To investigate reproducible surgical techniques to optimize the long-term safety of liquid crystal polymer (LCP)-based retinal prosthesis implantation. Methods:An LCP-based retinal prosthesis is fabricated monolithically on a single-body LCP substrate with all components, including the package and electrode ar...

journal_title：Translational vision science & technology

authors： Bae SH,Jeong J,Kim SJ,Chung H,Seo JM

更新日期：2018-08-24 00:00:00

abstract：Purposes:To investigate the limbal structure using anterior segment optical coherence tomography (AS-OCT) and compare the difference between a Chinese Han population and a Caucasian population. Methods:Sixty healthy Chinese Han subjects (109 eyes, Chinese group) and 32 healthy Caucasian subjects (51 eyes, Caucasian gr...

journal_title：Translational vision science & technology

authors： Le Q,Cordova D,Xu J,Deng SX

更新日期：2018-08-07 00:00:00

abstract：Purpose:To describe a new technique for mapping parafoveal intercapillary areas (PICAs) using optical coherence tomography angiography (OCTA), and demonstrate its utility for quantifying parafoveal nonperfusion in diabetic retinopathy (DR). Methods:Nineteen controls, 15 diabetics with no retinopathy (noDR), 15 with no...

journal_title：Translational vision science & technology

authors： Krawitz BD,Phillips E,Bavier RD,Mo S,Carroll J,Rosen RB,Chui TYP

更新日期：2018-07-12 00:00:00

abstract：Purpose:To demonstrate the presence of macular pigment in the retina of premature infants, and to examine its changes with age. Methods:The participants included 40 premature infants. Infants who had received laser photocoagulation for retinopathy of prematurity were excluded. Macular pigment optical density (MPOD) wa...

journal_title：Translational vision science & technology

authors： Sasano H,Obana A,Sharifzadeh M,Bernstein PS,Okazaki S,Gohto Y,Seto T,Gellermann W

更新日期：2018-07-09 00:00:00

abstract：Purpose:To examine repeatability and reproducibility of ellipsoid zone (EZ) width measurements in patients with retinitis pigmentosa (RP) using a longitudinal reflectivity profile (LRP) analysis. Methods:We examined Bioptigen optical coherence tomography (OCT) scans from 48 subjects with RP or Usher syndrome. Nominal ...

journal_title：Translational vision science & technology

authors： Strampe MR,Huckenpahler AL,Higgins BP,Tarima S,Visotcky A,Stepien KE,Kay CN,Carroll J

更新日期：2018-06-04 00:00:00

abstract：Purpose:Myopia is rising in prevalence in many locations, and there is evidence that outdoor light exposure is a major environmental factor playing a role in myopia development. This study examined the patterns of daily light exposure in similarly aged children from two geographic locations (Australia and Singapore) kn...

journal_title：Translational vision science & technology

authors： Read SA,Vincent SJ,Tan CS,Ngo C,Collins MJ,Saw SM

更新日期：2018-05-29 00:00:00

abstract：Purpose:To investigate the molecular components of the vitreous in order to better understand retinal physiology and disease. Methods:Vitreous was acquired from patients undergoing vitrectomy for macular hole and/or epiretinal membrane, postmortem donors, and C57BL/6J mice. Unbiased proteomic analysis was performed vi...

journal_title：Translational vision science & technology

authors： Zhao Y,Weber SR,Lease J,Russo M,Siedlecki CA,Xu LC,Chen H,Wang W,Ford M,Simó R,Sundstrom JM

更新日期：2018-05-14 00:00:00

abstract：:[This corrects the article on p. 4 in vol. 7.]. ...

journal_title：Translational vision science & technology

authors：

更新日期：2018-04-23 00:00:00

abstract：Purpose:This study aims to develop a fully automated algorithm for artery-vein (A-V) and arteriole-venule classification and to quantify the effect of hypertension on A-V caliber and tortuosity ratios of nonproliferative diabetic retinopathy (NPDR) patients. Methods:We combine an optical density ratio (ODR) analysis a...

journal_title：Translational vision science & technology

authors： Alam M,Son T,Toslak D,Lim JI,Yao X

更新日期：2018-04-18 00:00:00